Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response

Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response

<p>Abstract</p> <p>Background</p> <p>1-{4-[Bis(2-chloroethyl)amino]phenyl}-3-[2-methyl-5-(4-methylacridin-9-ylamino)phenyl]urea (BO-1051) is an N-mustard DNA alkylating agent reported to exhibit antitumor activity. Here we further investigate the effects of this compoun...

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Bibliographic Details
Main Authors: Chen Ming-Teh, Yen Sang-Hue, Chen Yi-Wei, Chen Li-Hsin, Lee Yi-Jang, Su Tsann-Long, Chiou Shih-Hwa, Chu Pei-Ming, Chen Ming-Hsiung, Shih Yang-Hsin, Tu Pang-Hsien, Ma Hsin-I
Format: Article
Language:English
Published: BMC 2011-01-01
Series:Radiation Oncology
Online Access:http://www.ro-journal.com/content/6/1/7

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http://www.ro-journal.com/content/6/1/7

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