The role of FoxP3+ regulatory T cells and IDO+ immune and tumor cells in malignant melanoma – an immunohistochemical study

The role of FoxP3+ regulatory T cells and IDO+ immune and tumor cells in malignant melanoma – an immunohistochemical study

Abstract Background FoxP3+ Regulatory T cells (Tregs) and indoleamine-2,3-dioxygenase (IDO) participate in the formation of an immunosuppressive tumor microenvironment (TME) in malignant cutaneous melanoma (CM). Recent studies have reported that IDO expression correlates with poor prognosis and grea...

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Bibliographic Details
Main Authors: Satu Salmi, Anton Lin, Benjamin Hirschovits-Gerz, Mari Valkonen, Niina Aaltonen, Reijo Sironen, Hanna Siiskonen, Sanna Pasonen-Seppänen
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Cancer
Subjects:
Melanoma
TME
Immunosuppression
Regulatory T cells
FoxP3
IDO
Online Access:https://doi.org/10.1186/s12885-021-08385-4

Internet

https://doi.org/10.1186/s12885-021-08385-4

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