Intestinal Microbiota at Engraftment Influence Acute Graft-Versus-Host Disease via the Treg/Th17 Balance in Allo-HSCT Recipients

Intestinal Microbiota at Engraftment Influence Acute Graft-Versus-Host Disease via the Treg/Th17 Balance in Allo-HSCT Recipients

Animal models have indicated that intestinal microbiota influence acute graft-versus-host disease (aGVHD) by modulating immune homeostasis. But, in humans, the mechanism by which the microbiota induces aGVHD remains unclear. In this study, we investigated the relationship between the intestinal micr...

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Bibliographic Details
Main Authors: Lijie Han, Hua Jin, Lizhi Zhou, Xin Zhang, Zhiping Fan, Min Dai, Qianyun Lin, Fen Huang, Li Xuan, Haiyan Zhang, Qifa Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
intestinal microbiota
histone acetylation
immune homeostasis
acute graft-versus-host disease
allogeneic hematopoietic stem cell transplantation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00669/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00669/full

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