Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP

Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP

The citrus flavonoids, naringenin and hesperetin, lower plasma cholesterol in vivo. However, the underlying mechanisms are not fully understood. The ability of these flavonoids to modulate apolipoprotein B (apoB) secretion and cellular cholesterol homeostasis was determined in the human hepatoma cel...

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Bibliographic Details
Main Authors: Lisa J. Wilcox, Nica M. Borradaile, Linda E. de Dreu, Murray W. Huff
Format: Article
Language:English
Published: Elsevier 2001-05-01
Series:Journal of Lipid Research
Subjects:
flavonoids
naringenin
hesperetin
apoB
microsomal triglyceride transfer protein
HepG2 cells
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520316345

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http://www.sciencedirect.com/science/article/pii/S0022227520316345

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