Metformin preferentially enhances the radio-sensitivity of cancer stem-like cells with highly mitochondrial respiration ability in HMPOS

Metformin preferentially enhances the radio-sensitivity of cancer stem-like cells with highly mitochondrial respiration ability in HMPOS

Metformin has many anti-cancer effects, alone or in combination with radiation. However, the mechanism underlying its radio-sensitized effect is still unclear, especially for cancer stem-like cells (CSCs). Here, the radio-sensitized effect of metformin was investigated, and its mechanism was reveale...

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Bibliographic Details
Main Authors: Tatsuya Deguchi, Kenji Hosoya, Shango Kim, Yusuke Murase, Kumiko Yamamoto, Tomoki Bo, Hironobu Yasui, Osamu Inanami, Mahiro Okumura
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
metformin
radiation
cancer stem-like cells
dog
mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521001182

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http://www.sciencedirect.com/science/article/pii/S2372770521001182

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