Synthetic Fragments of Receptor for Advanced Glycation End Products Bind Beta-Amyloid 1–40 and Protect Primary Brain Cells From Beta-Amyloid Toxicity

Synthetic Fragments of Receptor for Advanced Glycation End Products Bind Beta-Amyloid 1–40 and Protect Primary Brain Cells From Beta-Amyloid Toxicity

Receptor for advanced glycation end products (RAGE) is involved in the pathogenesis of Alzheimer’s disease. We have previously revealed that RAGE fragment sequence (60–76) and its shortened analogs sequence (60–70) and (60–65) under intranasal insertion were able to restore memory and improve morpho...

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Bibliographic Details
Main Authors: Anna V. Kamynina, Noemi Esteras, Dmitriy O. Koroev, Natalia V. Bobkova, Samson M. Balasanyants, Ruben A. Simonyan, Armine V. Avetisyan, Andrey Y. Abramov, Olga M. Volpina
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Neuroscience
Subjects:
beta-amyloid
synthetic peptides
receptor for advanced glycation end products
Alzheimer’s disease
primary cell culture
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00681/full

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https://www.frontiersin.org/article/10.3389/fnins.2018.00681/full

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