Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms.

Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms.

Cancer cells depend on transcription of telomerase reverse transcriptase (TERT). Many transcription factors affect TERT, though regulation occurs in context of a broader network. Network effects on telomerase regulation have not been investigated, though deeper understanding of TERT transcription re...

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Bibliographic Details
Main Authors: Alan E Bilsland, Katrina Stevenson, Yu Liu, Stacey Hoare, Claire J Cairney, Jon Roffey, W Nicol Keith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-02-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3923661?pdf=render

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http://europepmc.org/articles/PMC3923661?pdf=render

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