The Multi-Level Mechanism of Action of a Pan-Ras Inhibitor Explains its Antiproliferative Activity on Cetuximab-Resistant Cancer Cells

The Multi-Level Mechanism of Action of a Pan-Ras Inhibitor Explains its Antiproliferative Activity on Cetuximab-Resistant Cancer Cells

Ras oncoproteins play a crucial role in the onset, maintenance, and progression of the most common and deadly human cancers. Despite extensive research efforts, only a few mutant-specific Ras inhibitors have been reported. We show that cmp4–previously identified as a water-soluble Ras inhibitor– tar...

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Bibliographic Details
Main Authors: Renata Tisi, Michela Spinelli, Alessandro Palmioli, Cristina Airoldi, Paolo Cazzaniga, Daniela Besozzi, Marco S. Nobile, Elisa Mazzoleni, Simone Arnhold, Luca De Gioia, Rita Grandori, Francesco Peri, Marco Vanoni, Elena Sacco
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
RasG13D
RasG12V
anti-cancer agent
exchange factor
intrinsic nucleotide dissociation and exchange
Raf1 binding
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.625979/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.625979/full

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