A cooperative interaction between nontranslated RNA sequences and NS5A protein promotes in vivo fitness of a chimeric hepatitis C/GB virus B.

A cooperative interaction between nontranslated RNA sequences and NS5A protein promotes in vivo fitness of a chimeric hepatitis C/GB virus B.

GB virus B (GBV-B) is closely related to hepatitis C virus (HCV), infects small non-human primates, and is thus a valuable surrogate for studying HCV. Despite significant differences, the 5' nontranslated RNAs (NTRs) of these viruses fold into four similar structured domains (I-IV), with domain...

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Bibliographic Details
Main Authors: Lucile Warter, Lisette Cohen, Yann Benureau, Deborah Chavez, Yan Yang, Francis Bodola, Stanley M Lemon, Cinzia Traboni, Robert E Lanford, Annette Martin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2635954?pdf=render

Internet

http://europepmc.org/articles/PMC2635954?pdf=render

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