Estrogen exacerbates the nociceptive effects of peripheral serotonin on rat trigeminal sensory neurons

Estrogen exacerbates the nociceptive effects of peripheral serotonin on rat trigeminal sensory neurons

Orofacial pain disorders involving trigeminal sensory neurons disproportionately affect women and can be modulated by hormones, especially estrogen (E2). Proinflammatory mediators, like serotonin (5HT), can act on sensory neurons expressing the transient receptor potential vanilloid 1 (TRPV1) ion ch...

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Bibliographic Details
Main Authors: Sukhbir Kaur, Hanna McDonald, Sirima Tongkhuya, Cierra M.C. Lopez, Sushmitha Ananth, Taylor M. Hickman, Dayna L. Averitt
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Neurobiology of Pain
Subjects:
Estrogen
Serotonin
Pain
5HT2A receptor
Trigeminal sensory neurons
Online Access:http://www.sciencedirect.com/science/article/pii/S2452073X21000143

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http://www.sciencedirect.com/science/article/pii/S2452073X21000143

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