A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons

A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons

Abstract Background Midbrain dopaminergic neurons (MDN) represent 0.0005% of the brain’s neuronal population and mediate cognition, food intake, and metabolism. MDN are also posited to underlay the neurobiological dysfunction of schizophrenia (SCZ), a severe neuropsychiatric disorder that is charact...

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Main Authors: Sergio Espeso-Gil, Tobias Halene, Jaroslav Bendl, Bibi Kassim, Gabriella Ben Hutta, Marina Iskhakova, Neda Shokrian, Pavan Auluck, Behnam Javidfar, Prashanth Rajarajan, Sandhya Chandrasekaran, Cyril J. Peter, Alanna Cote, Rebecca Birnbaum, Will Liao, Tyler Borrman, Jennifer Wiseman, Aaron Bell, Michael J. Bannon, Panagiotis Roussos, John F. Crary, Zhiping Weng, Stefano Marenco, Barbara Lipska, Nadejda M. Tsankova, Laura Huckins, Yan Jiang, Schahram Akbarian
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Genome Medicine
Subjects:
Spatial genome
chrom3D
Euclidean hot spots
Shared nuclear territories
BMI GWAS
Schizophrenia GWAS
Online Access:http://link.springer.com/article/10.1186/s13073-020-0715-x

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http://link.springer.com/article/10.1186/s13073-020-0715-x

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