Abnormal repression of SHP-1, SHP-2 and SOCS-1 transcription sustains the activation of the JAK/STAT3 pathway and the progression of the disease in multiple myeloma.

Abnormal repression of SHP-1, SHP-2 and SOCS-1 transcription sustains the activation of the JAK/STAT3 pathway and the progression of the disease in multiple myeloma.

Sustained activation of JAK/STAT3 signaling pathway is classically described in Multiple Myeloma (MM). One explanation could be the silencing of the JAK/STAT suppressor genes, through the hypermethylation of SHP-1 and SOCS-1, previously demonstrated in MM cell lines or in whole bone marrow aspirates...

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Bibliographic Details
Main Authors: Asma Beldi-Ferchiou, Nour Skouri, Cyrine Ben Ali, Ines Safra, Abderrahman Abdelkefi, Saloua Ladeb, Karima Mrad, Tarek Ben Othman, Mélika Ben Ahmed
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5378363?pdf=render

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http://europepmc.org/articles/PMC5378363?pdf=render

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