Decomposing the Apoptosis Pathway Into Biologically Interpretable Principal Components

Principal component analysis (PCA) is one of the most common techniques in the analysis of biological data sets, but applying PCA raises 2 challenges. First, one must determine the number of significant principal components (PCs). Second, because each PC is a linear combination of genes, it rarely h...

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Bibliographic Details
Main Authors: Min Wang, Steven M Kornblau, Kevin R Coombes
Format: Article
Language:English
Published: SAGE Publishing 2018-05-01
Series:Cancer Informatics
Online Access:https://doi.org/10.1177/1176935118771082