Splicing factor SRSF1 promotes breast cancer progression via oncogenic splice switching of PTPMT1

Splicing factor SRSF1 promotes breast cancer progression via oncogenic splice switching of PTPMT1

Abstract Background Intensive evidence has highlighted the effect of aberrant alternative splicing (AS) events on cancer progression when triggered by dysregulation of the SR protein family. Nonetheless, the underlying mechanism in breast cancer (BRCA) remains elusive. Here we sought to explore the...

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Bibliographic Details
Main Authors: Jun-Xian Du, Yi-Hong Luo, Si-Jia Zhang, Biao Wang, Cong Chen, Gui-Qi Zhu, Ping Zhu, Cheng-Zhe Cai, Jing-Lei Wan, Jia-Liang Cai, Shi-Ping Chen, Zhi Dai, Wei Zhu
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Breast cancer
Alternative splicing
SRSF1
PTPMT1
P-AKT-C-MYC
Online Access:https://doi.org/10.1186/s13046-021-01978-8

Internet

https://doi.org/10.1186/s13046-021-01978-8

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