Do Neurons Require Astrocyte-Derived Lactate for Energy? Astrocyte-Neuron Metabolic Coupling is Mediated by Calcium Waves and Sodium Current in the Tripartite Synapse: Therapeutic Implications for Some Brain Diseases Involving Metabolic Dysregulation
The most widely accepted model of brain glucose metabolism is the astrocyte-neuron lactate shuttle (ANLS) hypothesis. However, in recent times, ANLS has met serious criticism as the model could not account for new data indicating that neurons may not require astrocyte-derived lactate for energy. Pro...
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| Format: | Article |
| Language: | English |
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Amber Publication
2018-10-01
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| Series: | Journal of Research in Medical and Dental Science |
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| Online Access: | https://www.jrmds.in/articles/do-neurons-require-astrocytederived-lactate-for-energy-astrocyteneuron-metabolic-coupling-is-mediated-by-calcium-waves-and-sodium-.pdf |