Constitutive Activation of NF-κB Pathway in Hematopoietic Stem Cells Causes Loss of Quiescence and Deregulated Transcription Factor Networks

Constitutive Activation of NF-κB Pathway in Hematopoietic Stem Cells Causes Loss of Quiescence and Deregulated Transcription Factor Networks

Identifying physiological roles of specific signaling pathways that regulate hematopoietic stem cell (HSC) functions may lead to new treatment strategies and therapeutic interventions for hematologic disorders. Here, we provide genetic evidence that constitutive activation of NF-κB in HSCs results i...

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Bibliographic Details
Main Authors: Masahiro Marshall Nakagawa, Huanwen Chen, Chozha Vendan Rathinam
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hematopoietic stem cells
NF-κB
quiescence
transcription factors
signal transduction
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2018.00143/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2018.00143/full

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