Human Peritoneal Mesothelial Cell Death Induced by High-Glucose Hypertonic Solution Involves Ca2+ and Na+ Ions and Oxidative Stress with the Participation of PKC/NOX2 and PI3K/Akt Pathways

Human Peritoneal Mesothelial Cell Death Induced by High-Glucose Hypertonic Solution Involves Ca2+ and Na+ Ions and Oxidative Stress with the Participation of PKC/NOX2 and PI3K/Akt Pathways

Chronic peritoneal dialysis (PD) therapy is equally efficient as hemodialysis while providing greater patient comfort and mobility. Therefore, PD is the treatment of choice for several types of renal patients. During PD, a high-glucose hyperosmotic (HGH) solution is administered into the peritoneal...

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Bibliographic Details
Main Authors: Felipe Simon, Pablo Tapia, Ricardo Armisen, Cesar Echeverria, Sebastian Gatica, Alejandro Vallejos, Alejandro Pacheco, Maria E. Sanhueza, Miriam Alvo, Erico Segovia, Rubén Torres
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Physiology
Subjects:
peritoneal tissue
mesothelial cell
cell death
hypertonicity
dialysis
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00379/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00379/full

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