Global Brain Transcriptome Analysis of a Neuronal Ceroid Lipofuscinoses Mouse Model
In humans, homozygous mutations in the TPP1 gene results in loss of tripeptidyl peptidase 1 (TPP1) enzymatic activity, leading to late infantile neuronal ceroid lipofuscinoses disease. Using a mouse model that targets the Tpp1 gene and recapitulates the pathology and clinical features of the human d...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-04-01
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| Series: | ASN Neuro |
| Online Access: | https://doi.org/10.1177/1759091419843393 |