Uncoupling Malt1 Threshold Function from Paracaspase Activity Results in Destructive Autoimmune Inflammation

Uncoupling Malt1 Threshold Function from Paracaspase Activity Results in Destructive Autoimmune Inflammation

The paracaspase Malt1 is a central regulator of antigen receptor signaling that is frequently mutated in human lymphoma. As a scaffold, it assembles protein complexes for NF-κB activation, and its proteolytic domain cleaves negative NF-κB regulators for signal enforcement. Still, the physiological f...

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Bibliographic Details
Main Authors: Andreas Gewies, Oliver Gorka, Hanna Bergmann, Konstanze Pechloff, Franziska Petermann, Katharina M. Jeltsch, Martina Rudelius, Mark Kriegsmann, Wilko Weichert, Marion Horsch, Johannes Beckers, Wolfgang Wurst, Mathias Heikenwalder, Thomas Korn, Vigo Heissmeyer, Jürgen Ruland
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714009139

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http://www.sciencedirect.com/science/article/pii/S2211124714009139

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