Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures

Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures

We recently demonstrated that recombinant adeno-associated viral vector-induced hippocampal overexpression of neuropeptide Y receptor, Y2, exerts a seizure-suppressant effect in kindling and kainate-induced models of epilepsy in rats. Interestingly, additional overexpression of neuropeptide Y in the...

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Bibliographic Details
Main Authors: Casper R. Gøtzsche, Litsa Nikitidou, Andreas T. Sørensen, Mikkel V. Olesen, Gunnar Sørensen, Søren H.O. Christiansen, Mikael Ängehagen, David P.D. Woldbye, Merab Kokaia
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Neurobiology of Disease
Subjects:
Y5 neuropeptide Y receptor
Adeno-associated viral vectors
Kainic acid seizures
Gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111002786

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http://www.sciencedirect.com/science/article/pii/S0969996111002786

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