mTORC1 Is Not Principally Involved in the Induction of Human Endotoxin Tolerance

mTORC1 Is Not Principally Involved in the Induction of Human Endotoxin Tolerance

Endotoxin tolerance represents a safeguard mechanism for preventing detrimental prolonged inflammation and exaggerated immune/inflammatory responses from innate immune cells to recurrent harmless pathogens. On the other hand, excessive immune tolerance can contribute to pathological immunosuppressio...

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Bibliographic Details
Main Authors: Kristin Ludwig, Ralf A. Husain, Ignacio Rubio
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
mTORC1
endotoxin tolerance
monocytes
macrophage
sepsis
immune suppression
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01515/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01515/full

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