Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease

Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease

The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, thus protecting various brain tissues as cortical neurons, for example. However, the effect of metformin on the substantia nigra (SN), the main structure affected in Parkinson’s di...

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Bibliographic Details
Main Authors: Khadija Tayara, Ana M. Espinosa-Oliva, Irene García-Domínguez, Afrah Abdul Ismaiel, Antonio Boza-Serrano, Tomas Deierborg, Alberto Machado, Antonio J. Herrera, José L. Venero, Rocío M. de Pablos
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neuroinflammation
Parkinson’s disease
metformin
microglia activation
animal model
AMPK
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00440/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00440/full

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