Extensive amplification of GI-VII-6, a multidrug resistance genomic island of Salmonella enterica serovar Typhimurium, increases resistance to extended-spectrum cephalosporins

Extensive amplification of GI-VII-6, a multidrug resistance genomic island of Salmonella enterica serovar Typhimurium, increases resistance to extended-spectrum cephalosporins

GI-VII-6 is a chromosomally integrated multidrug resistance genomic island harbored by a specific clone of Salmonella enterica serovar Typhimurium (S. Typhimurium). It contains a gene encoding CMY-2 β-lactamase (blaCMY-2), and therefore contributes to extended-spectrum cephalosporin resistance. To e...

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Bibliographic Details
Main Authors: Ken-ichi eLee, Masahiro eKusumoto, Tsuyoshi eSekizuka, Makoto eKuroda, Ikuo eUchida, Taketoshi eIwata, Susumu eOkamoto, Kimiko eYabe, Takashi eInaoka, Masato eAkiba
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Microbiology
Subjects:
Resistance
insertion sequence
Genomic island
Salmonella enterica serovar Typhimurium
gene duplication and amplification
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00078/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00078/full

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