MEKK1 Regulates Chemokine Expression in Mammary Fibroblasts: Implications for the Breast Tumor Microenvironment

MEKK1 Regulates Chemokine Expression in Mammary Fibroblasts: Implications for the Breast Tumor Microenvironment

Breast tumors contain both transformed epithelial cells and non-transformed stroma cells producing secreted factors that can promote metastasis. Previously, we demonstrated that the kinase MEKK1 regulates cell migration and gene expression, and that transgene-induced breast tumor metastasis is marke...

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Bibliographic Details
Main Authors: Saverio Gentile, Najmeh Eskandari, Michael A. Rieger, Bruce D. Cuevas
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
MEKK1
chemokine
gene expression
kinase
breast cancer
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.609918/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.609918/full

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