Paclitaxel Induces Upregulation of Transient Receptor Potential Vanilloid 1 Expression in the Rat Spinal Cord

Paclitaxel Induces Upregulation of Transient Receptor Potential Vanilloid 1 Expression in the Rat Spinal Cord

Painful peripheral neuropathy is a common adverse effect of paclitaxel (PTX) treatment. To analyze the contribution of transient receptor potential vanilloid 1 (TRPV1) in the development of PTX-induced mechanical allodynia/hyperalgesia and thermal hyperalgesia, TRPV1 expression in the rat spinal cor...

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Bibliographic Details
Main Authors: Yukako Kamata, Toshie Kambe, Terumasa Chiba, Ken Yamamoto, Kazuyoshi Kawakami, Kenji Abe, Kyoji Taguchi
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
paclitaxel
transient receptor potential vanilloid 1
spinal cord
peripheral neuropathic pain
TRPV1 antagonist
small interfering RNA
Online Access:https://www.mdpi.com/1422-0067/21/12/4341

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https://www.mdpi.com/1422-0067/21/12/4341

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