An association study between hypoxia inducible factor-1alpha (HIF-1α) polymorphisms and osteonecrosis.

An association study between hypoxia inducible factor-1alpha (HIF-1α) polymorphisms and osteonecrosis.

Bone hypoxia resulting from impaired blood flow is the final pathway for the development of osteonecrosis (ON). The aim of this study was to evaluate if HIF-1α, the major transcription factor triggered by hypoxia, is genetically implicated in susceptibility to ON. For this we analyzed frequencies of...

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Bibliographic Details
Main Authors: Georgia Chachami, Alkmini Kalousi, Loukia Papatheodorou, Aggeliki Lyberopoulou, Vasileios Nasikas, Keiji Tanimoto, George Simos, Konstantinos N Malizos, Eleni Georgatsou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3832621?pdf=render

Internet

http://europepmc.org/articles/PMC3832621?pdf=render

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