An association study between hypoxia inducible factor-1alpha (HIF-1α) polymorphisms and osteonecrosis.
Bone hypoxia resulting from impaired blood flow is the final pathway for the development of osteonecrosis (ON). The aim of this study was to evaluate if HIF-1α, the major transcription factor triggered by hypoxia, is genetically implicated in susceptibility to ON. For this we analyzed frequencies of...
Main Authors: | Georgia Chachami, Alkmini Kalousi, Loukia Papatheodorou, Aggeliki Lyberopoulou, Vasileios Nasikas, Keiji Tanimoto, George Simos, Konstantinos N Malizos, Eleni Georgatsou |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3832621?pdf=render |
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