Deletion of the complement C5a receptor alleviates the severity of acute pneumococcal otitis media following influenza A virus infection in mice.

Deletion of the complement C5a receptor alleviates the severity of acute pneumococcal otitis media following influenza A virus infection in mice.

There is considerable evidence that influenza A virus (IAV) promotes adherence, colonization, and superinfection by S. pneumoniae (Spn) and contributes to the pathogenesis of otitis media (OM). The complement system is a critical innate immune defense against both pathogens. To assess the role of th...

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Bibliographic Details
Main Authors: Hua Hua Tong, Garrett Lambert, Yong Xing Li, Joshua M Thurman, Gregory L Stahl, Kelsey Douthitt, Caitlin Clancy, Yujuan He, Andrew S Bowman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3989264?pdf=render

Internet

http://europepmc.org/articles/PMC3989264?pdf=render

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