Halothane binds to druggable sites in the [Ca2+]4-calmodulin (CaM) complex, but does not inhibit [Ca2+]4-CaM activation of kinase

Halothane binds to druggable sites in the [Ca2+]4-calmodulin (CaM) complex, but does not inhibit [Ca2+]4-CaM activation of kinase

The mechanism(s) of volatile anesthetics (VA) are poorly understood. We used high resolution NMR spectroscopy to determine the structure of the halothane/calmodulin([Ca2+]4-CaM) complex, and found that halothane molecules bind in the druggable sites. We then examined whether VA binding to d...

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Bibliographic Details
Main Authors: Juranić Nenad O., Jones Keith A., Penheiter Alan R., Hock Thomas J., Streiff John H.
Format: Article
Language:English
Published: Serbian Chemical Society 2013-01-01
Series:Journal of the Serbian Chemical Society
Subjects:
Volatile anesthetic
calmodulin
CaM
halothane
drugs
protein structure
Online Access:http://www.doiserbia.nb.rs/img/doi/0352-5139/2013/0352-51391300090J.pdf

Internet

http://www.doiserbia.nb.rs/img/doi/0352-5139/2013/0352-51391300090J.pdf

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