Discrete analysis of camelid variable domains: sequences, structures, and in-silico structure prediction

Discrete analysis of camelid variable domains: sequences, structures, and in-silico structure prediction

Antigen binding by antibodies requires precise orientation of the complementarity- determining region (CDR) loops in the variable domain to establish the correct contact surface. Members of the family Camelidae have a modified form of immunoglobulin gamma (IgG) with only heavy chains, called Heavy C...

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Bibliographic Details
Main Authors: Akhila Melarkode Vattekatte, Nicolas Ken Shinada, Tarun J. Narwani, Floriane Noël, Olivier Bertrand, Jean-Philippe Meyniel, Alain Malpertuy, Jean-Christophe Gelly, Frédéric Cadet, Alexandre G. de Brevern
Format: Article
Language:English
Published: PeerJ Inc. 2020-03-01
Series:PeerJ
Subjects:
Secondary structure
Nanobodies
Complementarity determining regions
Structural alphabet
Frameworks
Sequence structure relationship
Online Access:https://peerj.com/articles/8408.pdf

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https://peerj.com/articles/8408.pdf

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