p16Ink4a Prevents the Activation of Aged Quiescent Dentate Gyrus Stem Cells by Physical Exercise

p16Ink4a Prevents the Activation of Aged Quiescent Dentate Gyrus Stem Cells by Physical Exercise

In the neurogenic niches—the dentate gyrus of the hippocampus and the subventricular zone (SVZ) adjacent to lateral ventricles—stem cells continue to divide during adulthood, generating progenitor cells and new neurons, and to self-renew, thus maintaining the stem cell pool. During aging, the number...

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Bibliographic Details
Main Authors: Laura Micheli, Giorgio D’Andrea, Manuela Ceccarelli, Alessandra Ferri, Raffaella Scardigli, Felice Tirone
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
adult neurogenesis
dentate gyrus
neural stem cells
self-renewal
aging
physical exercise
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00010/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00010/full

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