Novel anti-bacterial activities of β-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation.

Novel anti-bacterial activities of β-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation.

Human β-defensins (hBD) are antimicrobial peptides that curb microbial activity. Although hBD's are primarily expressed by epithelial cells, we show that human platelets express hBD-1 that has both predicted and novel antibacterial activities. We observed that activated platelets surround Staph...

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Bibliographic Details
Main Authors: Bjoern F Kraemer, Robert A Campbell, Hansjörg Schwertz, Mark J Cody, Zechariah Franks, Neal D Tolley, Walter H A Kahr, Stephan Lindemann, Peter Seizer, Christian C Yost, Guy A Zimmerman, Andrew S Weyrich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-11-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3213094?pdf=render

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http://europepmc.org/articles/PMC3213094?pdf=render

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