Fucoidan, a Sulfated Polysaccharide, Inhibits Osteoclast Differentiation and Function by Modulating RANKL Signaling

Fucoidan, a Sulfated Polysaccharide, Inhibits Osteoclast Differentiation and Function by Modulating RANKL Signaling

Multinucleated osteoclasts differentiate from hematopoietic progenitors of the monocyte/macrophage lineage. Because of its pivotal role in bone resorption, regulation of osteoclast differentiation is a potential therapeutic approach to the treatment of erosive bone disease. In this study, we have fo...

Full description

Bibliographic Details
Main Authors: Young Woo Kim, Seung-Hoon Baek, Sang-Han Lee, Tae-Ho Kim, Shin-Yoon Kim
Format: Article
Language:English
Published: MDPI AG 2014-10-01
Series:International Journal of Molecular Sciences
Subjects:
fucoidan
osteoclastogenesis
sulfated polysaccharide
bone resorption
RANKL (receptor activator of nuclear factor kappa B (NF-κB) ligand)
Online Access:http://www.mdpi.com/1422-0067/15/10/18840

Internet

http://www.mdpi.com/1422-0067/15/10/18840

Similar Items