CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo

CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo

Abstract CARD-CC complexes involving BCL10 and MALT1 are major cellular signaling hubs. They govern NF-κB activation through their scaffolding properties as well as MALT1 paracaspase function, which cleaves substrates involved in NF-κB regulation. In human lymphocytes, gain-of-function defects in th...

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Bibliographic Details
Main Authors: Laura Israël, Anton Glück, Marjorie Berger, Marine Coral, Melanie Ceci, Adeline Unterreiner, Joëlle Rubert, Maureen Bardet, Stefanie Ginster, Alexandra M. Golding-Ochsenbein, Kea Martin, Thomas Hoyler, Thomas Calzascia, Grazyna Wieczorek, Rainer Hillenbrand, Stéphane Ferretti, Enrico Ferrero, Frédéric Bornancin
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-021-00321-2

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https://doi.org/10.1038/s41389-021-00321-2

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