Structural Variation of Chondroitin Sulfate Chains Contributes to the Molecular Heterogeneity of Perineuronal Nets

Structural Variation of Chondroitin Sulfate Chains Contributes to the Molecular Heterogeneity of Perineuronal Nets

Aggrecan, a chondroitin sulfate (CS) proteoglycan, forms lattice-like extracellular matrix structures called perineuronal nets (PNNs). Neocortical PNNs primarily ensheath parvalbumin-expressing inhibitory neurons (parvalbumin, PV cells) late in brain development. Emerging evidence indicates that PNN...

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Bibliographic Details
Main Authors: Shinji Miyata, Satomi Nadanaka, Michihiro Igarashi, Hiroshi Kitagawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Integrative Neuroscience
Subjects:
perineuronal nets
aggrecan
chondroitin sulfate
proteoglycan
parvalbumin-expressing neuron
Otx2
Online Access:http://journal.frontiersin.org/article/10.3389/fnint.2018.00003/full

Internet

http://journal.frontiersin.org/article/10.3389/fnint.2018.00003/full

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