Ciprofloxacin Derivatives Affect Parasite Cell Division and Increase the Survival of Mice Infected with Toxoplasma gondii.

Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is a worldwide disease whose clinical manifestations include encephalitis and congenital malformations in newborns. Previously, we described the synthesis of new ethyl-ester derivatives of the antibiotic ciprofloxacin with ~40-fold increased...

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Bibliographic Details
Main Authors: Erica S Martins-Duarte, Faustine Dubar, Philippe Lawton, Cristiane França da Silva, Maria de Nazaré C Soeiro, Wanderley de Souza, Christophe Biot, Rossiane C Vommaro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0125705