Engineering circular RNA for potent and stable translation in eukaryotic cells

Circular RNAs have recently been shown to have protein-coding potential. Here the authors design a self-splicing RNA that, when circularized, provides for stable high-yield protein production.

Bibliographic Details
Main Authors: R. Alexander Wesselhoeft, Piotr S. Kowalski, Daniel G. Anderson
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05096-6