Engineering circular RNA for potent and stable translation in eukaryotic cells
Circular RNAs have recently been shown to have protein-coding potential. Here the authors design a self-splicing RNA that, when circularized, provides for stable high-yield protein production.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05096-6 |
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doaj-130b5ea301d3466e9d0a07fec763a18b |
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Article |
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doaj-130b5ea301d3466e9d0a07fec763a18b2021-05-11T10:27:17ZengNature Publishing GroupNature Communications2041-17232018-07-019111010.1038/s41467-018-05096-6Engineering circular RNA for potent and stable translation in eukaryotic cellsR. Alexander Wesselhoeft0Piotr S. Kowalski1Daniel G. Anderson2David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of TechnologyDepartment of Chemical Engineering, Massachusetts Institute of TechnologyDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of TechnologyCircular RNAs have recently been shown to have protein-coding potential. Here the authors design a self-splicing RNA that, when circularized, provides for stable high-yield protein production.https://doi.org/10.1038/s41467-018-05096-6 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
R. Alexander Wesselhoeft Piotr S. Kowalski Daniel G. Anderson |
| spellingShingle |
R. Alexander Wesselhoeft Piotr S. Kowalski Daniel G. Anderson Engineering circular RNA for potent and stable translation in eukaryotic cells Nature Communications |
| author_facet |
R. Alexander Wesselhoeft Piotr S. Kowalski Daniel G. Anderson |
| author_sort |
R. Alexander Wesselhoeft |
| title |
Engineering circular RNA for potent and stable translation in eukaryotic cells |
| title_short |
Engineering circular RNA for potent and stable translation in eukaryotic cells |
| title_full |
Engineering circular RNA for potent and stable translation in eukaryotic cells |
| title_fullStr |
Engineering circular RNA for potent and stable translation in eukaryotic cells |
| title_full_unstemmed |
Engineering circular RNA for potent and stable translation in eukaryotic cells |
| title_sort |
engineering circular rna for potent and stable translation in eukaryotic cells |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-07-01 |
| description |
Circular RNAs have recently been shown to have protein-coding potential. Here the authors design a self-splicing RNA that, when circularized, provides for stable high-yield protein production. |
| url |
https://doi.org/10.1038/s41467-018-05096-6 |
| work_keys_str_mv |
AT ralexanderwesselhoeft engineeringcircularrnaforpotentandstabletranslationineukaryoticcells AT piotrskowalski engineeringcircularrnaforpotentandstabletranslationineukaryoticcells AT danielganderson engineeringcircularrnaforpotentandstabletranslationineukaryoticcells |
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1721448135183564800 |