Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression

Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression

<p>Abstract</p> <p>Background</p> <p>Randomized, double-blind, placebo-controlled trials constitute the gold standard in clinical research when testing the efficacy of new psychopharmacological interventions in the treatment of major depression. However, the blinded use...

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Bibliographic Details
Main Authors: Severus Emanuel, Seemüller Florian, Berger Michael, Dittmann Sandra, Obermeier Michael, Pfennig Andrea, Riedel Michael, Frangou Sophia, Möller Hans-Jürgen, Bauer Michael
Format: Article
Language:English
Published: BMC 2012-07-01
Series:BMC Medicine
Subjects:
major depression
clinical trials
randomized controlled trials
psychopharmacology
Online Access:http://www.biomedcentral.com/1741-7015/10/67

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http://www.biomedcentral.com/1741-7015/10/67

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