Tauroursodeoxycholic acid prevents Burkholderia pseudomallei-induced endoplasmic reticulum stress and is protective during melioidosis in mice

Tauroursodeoxycholic acid prevents Burkholderia pseudomallei-induced endoplasmic reticulum stress and is protective during melioidosis in mice

Abstract Background Burkholderia pseudomallei, a facultative intracellular bacterium, is the aetiological agent of melioidosis that is responsible for up to 40% sepsis-related mortality in epidemic areas. However, no effective vaccine is available currently, and the drug resistance is also a major p...

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Bibliographic Details
Main Authors: Siqi Yuan, Yao Fang, Mengling Tang, Zhiqiang Hu, Chenglong Rao, Jiangao Chen, Yupei Xia, Meijuan Zhang, Jingmin Yan, Bin Tang, Xiaoyi He, Jianping Xie, Xuhu Mao, Qian Li
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Microbiology
Subjects:
Burkholderia pseudomallei
Tauroursodeoxycholic acid
Endoplasmic reticulum stress
Apoptosis
Survival
Online Access:https://doi.org/10.1186/s12866-021-02199-x

Internet

https://doi.org/10.1186/s12866-021-02199-x

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