Taking promoters out of enhancers in sequence based predictions of tissue-specific mammalian enhancers

Taking promoters out of enhancers in sequence based predictions of tissue-specific mammalian enhancers

Abstract Background Many genetic diseases are caused by mutations in non-coding regions of the genome. These mutations are frequently found in enhancer sequences, causing disruption to the regulatory program of the cell. Enhancers are short regulatory sequences in the non-coding part of the genome t...

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Bibliographic Details
Main Authors: Julia Herman-Izycka, Michal Wlasnowolski, Bartek Wilczynski
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Medical Genomics
Subjects:
Enhancer prediction
Regulatory sequence
Histone modifications
Machine learning
Online Access:http://link.springer.com/article/10.1186/s12920-017-0264-3

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http://link.springer.com/article/10.1186/s12920-017-0264-3

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