Emerging role of SWI/SNF complex deficiency as a target of immune checkpoint blockade in human cancers
Abstract Mammalian SWI/SNF complex is a key chromatin remodeler that reshapes nucleosomes and regulates DNA accessibility. Mutations in SWI/SNF subunits are found in a broad spectrum of human cancers; however, the mechanisms of how these aberrations of SWI/SNF complex would impact tumorigenesis and...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-01-01
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| Series: | Oncogenesis |
| Online Access: | https://doi.org/10.1038/s41389-020-00296-6 |