Deep sequence analysis of non-small cell lung cancer: Integrated analysis of gene expression, alternative splicing, and single nucleotide variations in lung adenocarcinomas with and without oncogenic KRAS mutations

Deep sequence analysis of non-small cell lung cancer: Integrated analysis of gene expression, alternative splicing, and single nucleotide variations in lung adenocarcinomas with and without oncogenic KRAS mutations

KRAS mutations are highly prevalent in non-small cell lung cancer (NSCLC), and tumors harboring these mutations tend to be aggressive and resistant to chemotherapy. We used next-generation sequencing technology to identify pathways that are specifically altered in lung tumors harboring a KRAS mutati...

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Bibliographic Details
Main Authors: Krishna R Kalari, David eRossell, Brian M Necela, Yan W Asmann, Asha eNair, Saurabh eBaheti, Jennifer M Kachergus, Curtis S Younkin, Tiffany R Baker, Jennifer M Carr, Xiaojia eTang, Michael eWalsh, High Seng eChai, Zhifu eSun, Steven N Hart, Alexey A Leontovich, Asif eHossain, Jean-Pierre eKocher, Edith A Perez, David N Reisman, Alan P Fields, E. Aubrey eThompson
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-02-01
Series:Frontiers in Oncology
Subjects:
bioinformatics
Network analysis
RNA-Seq
computational methods
data integration
KRAS mutation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00012/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00012/full

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