Hyper-connectivity and hyper-plasticity in the medial prefrontal cortex in the valproic acid animal model of autism

The prefrontal cortex has been extensively implicated in autism to explain deficits in executive and other higher-order functions related to cognition, language, sociability and emotion. The possible changes at the level of the neuronal microcircuit are however not known. We studied microcircuit alt...

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Bibliographic Details
Main Authors: Tania Rinaldi, Catherine Perrodin, Henry Markram
Format: Article
Language:English
Published: Frontiers Media S.A. 2008-10-01
Series:Frontiers in Neural Circuits
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/neuro.04.004.2008/full