Establishment and evaluation of a transgenic mouse model of arthritis induced by overexpressing human tumor necrosis factor alpha

Establishment and evaluation of a transgenic mouse model of arthritis induced by overexpressing human tumor necrosis factor alpha

Tumor necrosis factor alpha (TNFα) plays a key role in the pathogenesis of rheumatoid arthritis (RA). Blockade of TNFα by monoclonal antibody has been widely used for the therapy of RA since the 1990s; however, its mechanism of efficacy, and potential safety concerns of the treatment are still not f...

Full description

Bibliographic Details
Main Authors: Ge Li, Yu'e Wu, Huanhuan Jia, Lu Tang, Ren Huang, Yucai Peng, Yu Zhang
Format: Article
Language:English
Published: The Company of Biologists 2016-04-01
Series:Biology Open
Subjects:
Animal model
Transgenic
TNFα
Rheumatoid arthritis
Synovial hyperplasia
Drug evaluation
Online Access:http://bio.biologists.org/content/5/4/418

Internet

http://bio.biologists.org/content/5/4/418

Similar Items