Inhibition of FGF2-Mediated Signaling in GIST—Promising Approach for Overcoming Resistance to Imatinib

Inhibition of FGF2-Mediated Signaling in GIST—Promising Approach for Overcoming Resistance to Imatinib

Inhibition of KIT-signaling is a major molecular target for gastrointestinal stromal tumor (GIST) therapy, and imatinib mesylate (IM) is known as the most effective first-line treatment option for patients with advanced, unresectable, and/or metastatic GISTs. We show here for the first time that the...

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Bibliographic Details
Main Authors: Sergei Boichuk, Aigul Galembikova, Ekaterina Mikheeva, Firuza Bikinieva, Aida Aukhadieva, Pavel Dunaev, Dinar Khalikov, Semen Petrov, Refat Kurtasanov, Elena Valeeva, Igor Kireev, Vera Dugina, Anna Lushnikova, Maria Novikova, Pavel Kopnin
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
gastrointestinal stromal tumors (GISTs)
imatinib (IM)
sunitinib (SU)
resistance
receptor tyrosine kinase (RTK)
c-KIT and FGFR-signaling
Online Access:https://www.mdpi.com/2072-6694/12/6/1674

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https://www.mdpi.com/2072-6694/12/6/1674

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