Thymoquinone protects against cardiac mitochondrial DNA loss, oxidative stress, inflammation and apoptosis in isoproterenol-induced myocardial infarction in rats

Thymoquinone protects against cardiac mitochondrial DNA loss, oxidative stress, inflammation and apoptosis in isoproterenol-induced myocardial infarction in rats

Introduction: Myocardial infarction (MI) is an ischemic life-threatening disease with exaggerated oxidative stress state that vigorously damages the cardiomyocyte membrane and subcellular structures, including the vital mitochondrial DNA (mtDNA). The mtDNA is responsible for the proper functionality...

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Bibliographic Details
Main Authors: Asmaa A. Khalifa, Radwa M. Rashad, Wessam F. El-Hadidy
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Heliyon
Subjects:
Isoproterenol
Thymoquinone
Cardiopotection
Cardiac mtDNA
Oxidative stress
Inflammatory cytokines
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844021016649

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http://www.sciencedirect.com/science/article/pii/S2405844021016649

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