Human norovirus targets enteroendocrine epithelial cells in the small intestine

Human norovirus pathogenesis is incompletely understood due to a lack of appropriate animal disease models. Here, Green et al. show norovirus replication in chromogranin A-positive enteroendocrine cells and other epithelial cells in tissue from a pediatric intestinal transplant recipient with severe...

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Main Authors: Kim Y. Green, Stuart S. Kaufman, Bianca M. Nagata, Natthawan Chaimongkol, Daniel Y. Kim, Eric A. Levenson, Christine M. Tin, Allison Behrle Yardley, Jordan A. Johnson, Ana Beatriz F. Barletta, Khalid M. Khan, Nada A. Yazigi, Sukanya Subramanian, Sangeetha R. Moturi, Thomas M. Fishbein, Ian N. Moore, Stanislav V. Sosnovtsev
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16491-3
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spelling doaj-132cb1be73ac4b169398e75cb96b5f8f2021-06-06T11:16:01ZengNature Publishing GroupNature Communications2041-17232020-06-0111111010.1038/s41467-020-16491-3Human norovirus targets enteroendocrine epithelial cells in the small intestineKim Y. Green0Stuart S. Kaufman1Bianca M. Nagata2Natthawan Chaimongkol3Daniel Y. Kim4Eric A. Levenson5Christine M. Tin6Allison Behrle Yardley7Jordan A. Johnson8Ana Beatriz F. Barletta9Khalid M. Khan10Nada A. Yazigi11Sukanya Subramanian12Sangeetha R. Moturi13Thomas M. Fishbein14Ian N. Moore15Stanislav V. Sosnovtsev16Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthMedStar Georgetown Transplant Institute and Georgetown University Medical CenterInfectious Disease Pathogenesis Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of HealthCaliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthCaliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthCaliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthCaliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthCaliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthCaliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthMosquito Immunity and Vector Competence Section, National Institute of Allergy and Infectious Diseases, National Institutes of HealthMedStar Georgetown Transplant Institute and Georgetown University Medical CenterMedStar Georgetown Transplant Institute and Georgetown University Medical CenterMedStar Georgetown Transplant Institute and Georgetown University Medical CenterMedStar Georgetown Transplant Institute and Georgetown University Medical CenterMedStar Georgetown Transplant Institute and Georgetown University Medical CenterInfectious Disease Pathogenesis Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of HealthCaliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthHuman norovirus pathogenesis is incompletely understood due to a lack of appropriate animal disease models. Here, Green et al. show norovirus replication in chromogranin A-positive enteroendocrine cells and other epithelial cells in tissue from a pediatric intestinal transplant recipient with severe gastroenteritis.https://doi.org/10.1038/s41467-020-16491-3
collection DOAJ
language English
format Article
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author Kim Y. Green
Stuart S. Kaufman
Bianca M. Nagata
Natthawan Chaimongkol
Daniel Y. Kim
Eric A. Levenson
Christine M. Tin
Allison Behrle Yardley
Jordan A. Johnson
Ana Beatriz F. Barletta
Khalid M. Khan
Nada A. Yazigi
Sukanya Subramanian
Sangeetha R. Moturi
Thomas M. Fishbein
Ian N. Moore
Stanislav V. Sosnovtsev
spellingShingle Kim Y. Green
Stuart S. Kaufman
Bianca M. Nagata
Natthawan Chaimongkol
Daniel Y. Kim
Eric A. Levenson
Christine M. Tin
Allison Behrle Yardley
Jordan A. Johnson
Ana Beatriz F. Barletta
Khalid M. Khan
Nada A. Yazigi
Sukanya Subramanian
Sangeetha R. Moturi
Thomas M. Fishbein
Ian N. Moore
Stanislav V. Sosnovtsev
Human norovirus targets enteroendocrine epithelial cells in the small intestine
Nature Communications
author_facet Kim Y. Green
Stuart S. Kaufman
Bianca M. Nagata
Natthawan Chaimongkol
Daniel Y. Kim
Eric A. Levenson
Christine M. Tin
Allison Behrle Yardley
Jordan A. Johnson
Ana Beatriz F. Barletta
Khalid M. Khan
Nada A. Yazigi
Sukanya Subramanian
Sangeetha R. Moturi
Thomas M. Fishbein
Ian N. Moore
Stanislav V. Sosnovtsev
author_sort Kim Y. Green
title Human norovirus targets enteroendocrine epithelial cells in the small intestine
title_short Human norovirus targets enteroendocrine epithelial cells in the small intestine
title_full Human norovirus targets enteroendocrine epithelial cells in the small intestine
title_fullStr Human norovirus targets enteroendocrine epithelial cells in the small intestine
title_full_unstemmed Human norovirus targets enteroendocrine epithelial cells in the small intestine
title_sort human norovirus targets enteroendocrine epithelial cells in the small intestine
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-06-01
description Human norovirus pathogenesis is incompletely understood due to a lack of appropriate animal disease models. Here, Green et al. show norovirus replication in chromogranin A-positive enteroendocrine cells and other epithelial cells in tissue from a pediatric intestinal transplant recipient with severe gastroenteritis.
url https://doi.org/10.1038/s41467-020-16491-3
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