Human norovirus targets enteroendocrine epithelial cells in the small intestine
Human norovirus pathogenesis is incompletely understood due to a lack of appropriate animal disease models. Here, Green et al. show norovirus replication in chromogranin A-positive enteroendocrine cells and other epithelial cells in tissue from a pediatric intestinal transplant recipient with severe...
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| Language: | English |
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Nature Publishing Group
2020-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16491-3 |
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doaj-132cb1be73ac4b169398e75cb96b5f8f2021-06-06T11:16:01ZengNature Publishing GroupNature Communications2041-17232020-06-0111111010.1038/s41467-020-16491-3Human norovirus targets enteroendocrine epithelial cells in the small intestineKim Y. Green0Stuart S. Kaufman1Bianca M. Nagata2Natthawan Chaimongkol3Daniel Y. Kim4Eric A. Levenson5Christine M. Tin6Allison Behrle Yardley7Jordan A. Johnson8Ana Beatriz F. Barletta9Khalid M. Khan10Nada A. Yazigi11Sukanya Subramanian12Sangeetha R. Moturi13Thomas M. Fishbein14Ian N. Moore15Stanislav V. Sosnovtsev16Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthMedStar Georgetown Transplant Institute and Georgetown University Medical CenterInfectious Disease Pathogenesis Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of HealthCaliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthCaliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthCaliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthCaliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthCaliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthCaliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthMosquito Immunity and Vector Competence Section, National Institute of Allergy and Infectious Diseases, National Institutes of HealthMedStar Georgetown Transplant Institute and Georgetown University Medical CenterMedStar Georgetown Transplant Institute and Georgetown University Medical CenterMedStar Georgetown Transplant Institute and Georgetown University Medical CenterMedStar Georgetown Transplant Institute and Georgetown University Medical CenterMedStar Georgetown Transplant Institute and Georgetown University Medical CenterInfectious Disease Pathogenesis Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of HealthCaliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthHuman norovirus pathogenesis is incompletely understood due to a lack of appropriate animal disease models. Here, Green et al. show norovirus replication in chromogranin A-positive enteroendocrine cells and other epithelial cells in tissue from a pediatric intestinal transplant recipient with severe gastroenteritis.https://doi.org/10.1038/s41467-020-16491-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kim Y. Green Stuart S. Kaufman Bianca M. Nagata Natthawan Chaimongkol Daniel Y. Kim Eric A. Levenson Christine M. Tin Allison Behrle Yardley Jordan A. Johnson Ana Beatriz F. Barletta Khalid M. Khan Nada A. Yazigi Sukanya Subramanian Sangeetha R. Moturi Thomas M. Fishbein Ian N. Moore Stanislav V. Sosnovtsev |
| spellingShingle |
Kim Y. Green Stuart S. Kaufman Bianca M. Nagata Natthawan Chaimongkol Daniel Y. Kim Eric A. Levenson Christine M. Tin Allison Behrle Yardley Jordan A. Johnson Ana Beatriz F. Barletta Khalid M. Khan Nada A. Yazigi Sukanya Subramanian Sangeetha R. Moturi Thomas M. Fishbein Ian N. Moore Stanislav V. Sosnovtsev Human norovirus targets enteroendocrine epithelial cells in the small intestine Nature Communications |
| author_facet |
Kim Y. Green Stuart S. Kaufman Bianca M. Nagata Natthawan Chaimongkol Daniel Y. Kim Eric A. Levenson Christine M. Tin Allison Behrle Yardley Jordan A. Johnson Ana Beatriz F. Barletta Khalid M. Khan Nada A. Yazigi Sukanya Subramanian Sangeetha R. Moturi Thomas M. Fishbein Ian N. Moore Stanislav V. Sosnovtsev |
| author_sort |
Kim Y. Green |
| title |
Human norovirus targets enteroendocrine epithelial cells in the small intestine |
| title_short |
Human norovirus targets enteroendocrine epithelial cells in the small intestine |
| title_full |
Human norovirus targets enteroendocrine epithelial cells in the small intestine |
| title_fullStr |
Human norovirus targets enteroendocrine epithelial cells in the small intestine |
| title_full_unstemmed |
Human norovirus targets enteroendocrine epithelial cells in the small intestine |
| title_sort |
human norovirus targets enteroendocrine epithelial cells in the small intestine |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-06-01 |
| description |
Human norovirus pathogenesis is incompletely understood due to a lack of appropriate animal disease models. Here, Green et al. show norovirus replication in chromogranin A-positive enteroendocrine cells and other epithelial cells in tissue from a pediatric intestinal transplant recipient with severe gastroenteritis. |
| url |
https://doi.org/10.1038/s41467-020-16491-3 |
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