Effect of adoptive transfer or depletion of regulatory T cells on triptolide-induced liver injury

Effect of adoptive transfer or depletion of regulatory T cells on triptolide-induced liver injury

ObjectiveThe aim of this study is to clarify the role of regulatory T cell (Treg) in triptolide (TP)-induced hepatotoxicity. MethodsFemale C57BL/6 mice received either adoptive transfer of Tregs or depletion of Tregs, then underwent TP administration and were sacrificed 24 hours after TP administrat...

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Bibliographic Details
Main Authors: Xinzhi eWang, Lixin eSun, Luyong eZhang, Zhenzhou eJiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Pharmacology
Subjects:
Interleukin-10
Hepatotoxicity
Notch signaling
Triptolide
Regulatory T cell (Treg)
Suppressor of cytokine signaling(SOCS)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00099/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00099/full

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