Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis

When grown in the lab, Mycobacterium tuberculosis can form pellicle biofilms. Here, Trivedi et al. show that thiol reductive stress (induced by dithiothreitol) triggers rapid formation of thicker biofilms containing cellulose as well as antibiotic-tolerant, metabolically active bacteria.

Bibliographic Details
Main Authors: Abhishek Trivedi, Parminder Singh Mavi, Deepak Bhatt, Ashwani Kumar
Format: Article
Language:English
Published: Nature Publishing Group 2016-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11392